Human Biology for Biomedical Engineering II

课程简介

/ Indicative Syllabus (Note 2) Module 1: Basic Disease Processes (week 1 to 5) 1. Define the basic terminology of pathophysiology in injury, infection and cancer, and the basic categories of disease by general mechanisms (genetic/ developmental/degenerative) and specific causes (ischemic, infectious, immune, 1metabolic, trauma, idiopathic); describe basic diagnostic tools ranging from routine laboratory tests to advanced imaging modalities; discuss engineering innovations for better health (link with other BME subjects); 2. Articulate basic process of injury and repair, and compare reparative process among neuromusculokeletal tissues (e.g. brain/spinal cord injury, fractures, dislocation, sprain and strains); 3. Understand the process of innate and adaptive immune responses to virus and bacteria infections. 4. Describe various processes of altered cellular growth including hypertrophy, hyperplasia, metaplasia, dysplasia and neoplasia, and appreciate the similarities and differences between the biological behaviors of benign versus malignant neoplasms; 5. Appreciate chromosomal abnormalities, single gene abnormalities and multifactorial inheritance as causes of disease e.g. cerebral palsy, Duchenne muscular dystrophy etc. A blood laboratory session will be arranged to understand basic concept of diagnostic tests and results interpretation. Module two: integrated organs/systems responses to stressors (week 6 to 9) 6. Iterate the functional anatomy of limbs and spine, and basic quantitative evaluations; 7. Discuss the adaptive responses of musculoskeletal tissues to the common stressors, i.e. diet and exercise, neuroendocrine regulation of calcium homeostasis, growth and remodeling of bone, and related diseases such as rickets and osteomalacia; 8. Explain maladaptive responses of musculoskeletal system to obesity and ageing e.g. sarcopenia, osteoporosis and osteoarthritis; A histology laboratory session will be arranged to understand the pathological changes of musculoskeletal system post injury at organ, tissue to cellular levels. Module three: Major organ-related diseases (week 10 to 13) 9. Develop the understanding of the following aspects of the major human diseases: incidence or prevalence, cause, clinical manifestations, diagnosis, treatment, prognosis. In this module, we will discuss the prevalent neurodegenerative (e.g. Alzheimer’s disease, Parkinson’s disease), cerebro-cardiovascular disease (e.g. hypertension, ischemic heart disease and stroke) and metabolic syndrome (e.g. diabetes, obesity). A practical laboratory session will be arranged to understand neuromuscular junction.

目标

This course aims to introduce the basic concept and processes of human diseases to the undergraduate students of biomedical engineering for the effective communications/interactions across the biology, medicine and engineering disciplines.