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/ Indicative Syllabus Pentose phosphate pathway and reducing equivalents; anaplerotic reactions and carbohydrate metabolism; glycogen synthesis and breakdown; common diseases of carbohydrate metabolism. (8 hours) Amino acid metabolism: synthesis of amino acids from intermediates of the citric acid cycle; synthesis of glutamine, proline and arginine from glutamate; synthesis of serine, cysteine, histidine and aromatic amino acids; regulation of amino acid biosynthesis; urea cycle; common diseases of amino acid metabolism. (8 hours) Lipid metabolism: synthesis of triacylglycerol and membrane lipids; metabolism of cholesterol and steroid hormones; turnover of fats and lipoproteins; common diseases of lipid metabolism. (14 hours) Nucleotide metabolism: biosynthesis and catabolism of nucleotides. Cancer drugs targeting nucleotide metabolism pathways. (6 hours) Vitamins and coenzymes, essential and trace minerals: their role in metabolism and common diseases. (4 hours) Xenobiotics metabolism: Cytochrome P450; drug and toxin metabolism. (3 hours) -- 1 of 3 --
/ Indicative Syllabus Basic principles of Pharmacology: - History of pharmacology and its relationship with biotech disciplines. - Definition, nature and sources of drugs, drug nomenclature. - Effects of drugs on the body---pharmacodynamics - Effects of the body on drugs---pharmacokinetics - Basic principles of toxicology and adverse drug reactions - Adverse drug effects in the geriatric population - Research and development of new drugs including biologic products. - Drug regulation and legislation. Pharmacology of the autonomic and central nervous systems: - Basic principles of neural transmission. - Drugs affecting the autonomic nervous system. - Drugs affecting the central nervous system. - Drugs for neurological and psychiatric disorders. Drugs affecting major organ system: - Basic principles and drugs for cardiovascular disorders - Basic principles and drugs for disorders in endocrine system. -- 1 of 3 -- - Basic principles and drugs for antimicrobial/antiviral chemotherapy. - Basic principles and drugs for cancer chemotherapy. Basic principles of toxicology and risk
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暂无评分/ Indicative Syllabus Topic Hour Screening and development of microbial metabolites for commercial production 2 Development of industrial microorganisms • isolation, screening and genetic development of industrial microbes 7 Microbial growth kinetics and Fermentation systems • batch, fed-batch and continuous culture 7 Fermentation media • media formulation and optimization 3 Microbes in the food industry • use of microorganisms in the production of food and food ingredients. 7 Pharmaceutical microbiology • use of microorganisms in the production of antibiotics, steroid hormones and health related products 7 Microorganisms in the chemical industry • use of microorganisms in the production of fuels, 6 -- 1 of 2 -- chemicals and new materials. Microbial leaching Agricultural Microbiology • bioinsecticides, bioherbicides and related products 4 Total 43
/ Indicative Syllabus The Project involves a literature search/review or investigation of a fundamental or practical topic in applied biology and biotechnology. A small amount of experimental work is permitted although not required. The project could be basic studies on biological compounds, development of methods/products/equipment, design and evaluation of bioprocesses, and feasibility study/survey on the marketing of biological products.
/ Indicative Syllabus The Research Project may involve an experimental investigation of a fundamental or practical problem in applied biology and biotechnology. The project could be basic studies on biological compounds, development of methods/products/ equipment, design and evaluation of bioprocesses, and feasibility study/survey on the marketing of biological products.
/ Indicative Syllabus The Project involves a study on a fundamental or practical topic in applied biology and biotechnology. The study consists of literature survey and an experimental investigation. The project could be mechanistic studies on biological processes, development of methods/products/equipment, design and evaluation of bioprocesses, and feasibility study/survey on the marketing of biological products.
/ Indicative Syllabus Principles of sequencing technologies, sequence assembly, sequence alignment, variant identification and annotation, DNA foundation models, genome editing Hands-on tutorial of FastQC, Megahit, BLAST Principles of RNA sequencing, RNA read mapping, gene expression quantification, differential gene expression analysis, gene set enrichment analysis Hands-on tutorial of DESeq2, g:Profiler, MetaScape, GSEA Basic concepts of gene regulatory elements, analysis of transcription factors, DNA methylation, chromatin accessibility, histone modification, three- dimensional genome Single cell sequencing technologies, characteristics of single cell data, dimensionality reduction, cell type annotation, single cell foundation models, spatial omics techniques Hands-on tutorial of single cell RNA sequencing data analysis using Seurat -- 1 of 3 -- Basics of proteomics, basic theory of biological mass spectrometry (MS) and liquid chromatography-MS instruments, protein identification, quantitative proteomics, post-translational modifications (PTMs), data analysis and bioinformatics of MS data. Basics of metabolites and techniques in metabolomics, pre-process, process and analyse metabolomics data using univariate and multivariate data analysis, metabolomics downstream analyses for metabolic pathway and network analysis, and brief introduction of multi-omics. Hands-on tutorial of metabolomics data analysis using MetaboAnalyst
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暂无评分/ Indicative Syllabus The project will involve different experimental investigations, also bioinformatics elements. Synthetic biology knowledge will be applied to initiate ideas, design experiments and evaluate bioprocesses. Conducting survey on the feasibility of the projects to field experts and promoting to the public about the ideas will be included as well.
/ Indicative Syllabus Special tissue handling: • Various types of biopsy sample handling and processing Histopathology: • Basic concepts in identification of abnormal cells and pathological features in tumours and malignancy Cytology: • Sample collection and processing • Cytological smear preparation and staining • Cytological features of normal cellular constituents, common changes shown in cells in relation to disease and associated malignancy Advanced laboratory technologies in Anatomical Pathology: • Immunohistochemistry (IHC) and immunocytochemistry (ICC) • Molecular diagnosis in Anatomical Pathology • Electron microscopy -- 1 of 3 --
/ Indicative Syllabus Introduction Principles in waste management and control; role and deeds of Hong Kong Government on environmental management; policy and environmental regulations on waste management. Wastewater characteristics; primary, secondary and tertiary treatments of wastewater; physical, chemical and biological treatment processes; sewage sludge production; wastewater analysis: BOD, COD, suspended solids, turbidity, etc. Wastewater Management and Treatment Water quality requirements and characteristics; conservation of water; requirements for water utilization in food and food processing; tests for water quality; principles of water treatment. Water Management and Treatment Sources and classification of food and municipal solid waste; waste minimization, collection, processing, anaerobic digestion, incineration and landfill;
/ Indicative Syllabus Test Methods • Types and roles of test methods • Criteria approach for selection of test methods • Validation/verification of test methods • Quality control practices Measurement Uncertainty • Statistical tools for treatment of data from analysis and measurement • Estimation of measurement uncertainty based on relevant international practices • Reporting and interpretation of test results taking into consideration of measurement uncertainty
/ Indicative Syllabus Overview of Certification and Inspection • Roles of certification and inspection • Ethical issues • General and management requirements Introduction to International Standards for Certification Bodies • ISO/IEC 17021 for bodies providing audit and certification of management systems • ISO/IEC 17065 for bodies certifying products, processes and services • ISO/IEC 17024 for bodies operating certification of persons Introduction to International Standard for Inspection Bodies • ISO/IEC 17020 for bodies performing inspection Highlights of Requirements • Role of testing and calibration in certification and inspection Accreditation of Certification Bodies and Inspection Bodies • IAF, HKCAS, HKIAS • Accreditation process
/ Indicative Syllabus Quality Management System • ISO 9001 international standard on quality management systems • Quality management principles • Management requirements Laboratory Management System • ISO/IEC 17025 international standard on laboratory management system • Management and technical requirements Laboratory Accreditation • International Laboratory Accreditation Cooperation (ILAC) and Hong Kong Laboratory Accreditation Scheme (HOKLAS) • HOKLAS general requirements and supplementary criteria • Laboratory accreditation process
/ Indicative Syllabus Introduction to Sustainability and ESG Waste Management ESG for business and industry Climate Risk Management Sustainability Development in Hong Kong and Mainland Technology and Innovation for Sustainability ESG Impact of Artificial Intelligence -- 1 of 4 -- 2
/ Indicative Syllabus Fundamental Principles of Laboratory Information Management Systems (LIMS) and Laboratory Automation • Overview of LIMS and automation • Historical development & components of LIMS • Benefits of implementing LIMS and automation Core components of LIMS and Laboratory Automation • Protocols for laboratory workflows • Sensors, actuators and controllers in laboratory automation • Basics of robotic systems • Common communication protocols Digital Transformation and Internet of Things (IoT) Fundamentals for LIMS and Laboratory Automation • IoT architecture: sensors, gateways, cloud platforms, etc • Cloud-based solutions on laboratories • Data security in IoT-enabled laboratories Quality Assurance and Compliance with International Standards • Quality Assurance and Control • ISO/IEC 17025 • ISO 15189 LIMS Integration and Data Management • Inventory Management • Personnel and Training • Equipment Management and Maintenance • Data Management, Analysis, Decision Making and Reporting Integrating Artificial Intelligence (AI) in solving real-world LIMS and Laboratory Automation • Introduction to AI/ Machine Learning • Automated data collection • Use of progamming language such as Python and GenAI in setting up laboratory automation • Integration with various instrumentation • Application of AI in data analysis and visualization for compliance in real-world cases
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暂无评分/ Indicative Syllabus Overview of Laboratory Operation • Organizational structure and roles; • Laboratory environment and resource management • General operating system and procedures Environmental Testing • Topical issues, regulations and test standards for air, water and waste samples • Sampling and handling of test samples • Ultra-trace analysis, such as dioxins • Case studies Medicinal Testing • Topical issues, regulations and test standards for pharmaceutical products and Chinese medicines; • Case studies Food Testing • Topical issues, regulations and test standards for food additives, contaminants and residues as well as for nutrition labeling • Sampling for test portions • Multi-residues analysis • Case studies Other Commodity Testing • Topical issues, regulations and test standards for other commodities, such as toys and children’s products, construction materials, precious metals, etc. • Case studies -- 1 of 2 --
/ Indicative Syllabus Project could be an experimental investigation of the identity and quantity of a selected target in real sample matrix. The detailed theory, methodology and experimental procedure will be proposed by student. Analytical data collected by the student will be processed and presented in form of oral presentation and final report. Students can benefit greatly from problems/investigations in the real-world situations
/ Indicative Syllabus • Introduction and Statistics Review • Statistical Process Control (SPC) • Acceptance Sampling and Inspection • Principles of Quality Management • International Standard for Quality Management System (ISO 9000) • Hong Kong Laboratory Accreditation Scheme (HOKLAS)
/ Indicative Syllabus (Note 2) A study of an assigned problem in analytical chemistry. The study consists of literature survey and an investigation. The investigation should include a research element and may include field work or experimental study on topics in analytical chemistry.
/ Indicative Syllabus Molecular spectroscopy and photochemistry Fundamental Postulates of quantum mechanics, solutions of Schrodinger equation for rigid rotor and harmonic oscillator, Born-Oppenheimer approximation, computational methods, spectra of diatomic molecules: rotational spectra, vibrational spectra, vibration-rotation spectra, electronic spectra, selection rules. Photochemical processes: photochemical principles, pathways of molecular excitation, fluorescence and phosphorescence, quantum yield. Laser and industrial application. Materials Crystal : crystal systems, space lattice, Miller index, crystal structures, types of crystal defect and their physical significance. Liquid crystal, ceramics, semi-conductors, superconductors, nanostructures. X-ray diffraction techniques: powder method, single crystal diffraction. Surface probing techniques: electron spectroscopy, low-energy electron diffraction, field emission and ionization microscopy, scanning tunnelling microscopy.
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