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ABCT1742abct3 credits

General Chemistry II

/ Indicative Syllabus Properties of Gases The simple gas laws, Ideal Gas Equation and its application, non-ideal gases Electrons in Atoms Electromagnetic radiation, atomic spectra, quantum theory, the Bohr’s atom, wave mechanics, uncertainty principle, quantum numbers and atomic orbitals, hydrogen atom and many electron atoms, electronic configurations Periodic Table and Atomic Properties Classification of chemical elements, sizes of atoms and ions, ionization energy, electronic affinity, magnetic properties, periodic properties of the elements Chemical Bonding – Localized Electron Pair Approach -- 1 of 3 -- Lewis theory and Octet rule, limitation of the Lewis theory, bond energies and bond distances, polar covalent bonds, VSEPR theory and molecular shapes of polyatomic molecules, physical properties and molecular shapes, Valence Bond theory Chemical Bonding – Delocalized Electron Pair Approach Principles of Molecular Orbital (MO) theory for homonuclear and heteronuclear diatomic molecules; bonding and antibonding molecular orbitals; MO energy-level diagrams; election configurations and physical properties (e.g. bond order, magnetism, etc), frontier orbitals, delocalized π-bonding in polyatomic molecules, Band theory of solids Intermolecular Forces and Properties of Liquids Dipole-dipole interaction, ion-dipole interaction, van der Waals forces, hydrogen bonding, physical properties of liquid (e.g. viscosity, surface tension), phase transition and energetics Chemistry of Transition Metals Electronic configurations and general properties of transition metals; co- ordination compounds; ligands and co-ordination numbers; formation constant for complex in equilibria; chelate effects; structure and isomerism of coordination compounds; crystal field splitting in complexes; color and magnetic properties of complexes; applications of co-ordination compounds

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ABCT1D01:ABCT1301abct3 credits

Chemistry and Modern Living

/ Indicative Syllabus Topics Contact Hours The nature of matter – elements, compounds and mixtures; atoms and molecules 4 Periodic Table and Chemical Bonding 6 Modern materials –plastics 4 Chemistry of Air: Acid rain, ozone hole and global w arming 4 Energy for Today and Tomorrow 6 Chemistry of Water: Water treatment and recycling 4 Chemistry in Health and Medicine 6 Chemistry of Food Chemistry that keep you beautiful and clean 4

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ABCT1D03:ABCT1303abct3 credits

Biotechnology and Human Health

/ Indicative Syllabus THE DEVELOPMENT OF MODERN BIOTECHNOLOGY: 2 Hrs Brief history and different areas of biotechnology The impact of biotechnology on society FUNDEMENTAL PRINCIPLES OF LIFE: 2 Hrs Cell structure and flow of genetic information Cell metabolism, growth and development GENE BIOTECHNOLOGY 4 Hrs Techniques for analyzing DNA Human Genome Project Genetic engineering and gene therapy PROTEIN BIOTECHNOLOGY 4 Hrs Diverse uses of proteins as biotechnology products Protein engineering for therapeutic uses VIRUS AND IMMUNO BIOTECHNLOGY 4 Hrs Virus and infectious diseases Antibodies and vaccines MICROBIAL BIOTECHNOLOGY 3 Hrs Microbial infection and antibiotics Yeast and fermentation ANIMAL BIOTECHNOLOGY 4 Hrs Genetically modified animals as disease models Embryos, clones and animal cloning Transgenic animal and its application MEDICAL BIOTECHNOLOGY 4 Hrs Medical detection and diagnosis Drug discovery through modern biotechnology Stem cell technology and regenerative medicine GREEN BIOTECHNOLOGY 4 Hrs Transgenic plants and biotechnology in agriculture -- 2 of 4 -- 3 Green energy and biofuels THE BIOTECHNOLOGY INDUSTRY 2 Hrs Economics; ethics and regulation Future strategies and challenges

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ABCT1D04:ABCT1101abct3 credits

Introductory Life Science

/ Indicative Syllabus Contact Hours The basics of life forms: 6 Hrs (1) The different forms of biological organisms, i.e. Viruses, Bacteria, Protozoa, Algae, Fungi, Plants, Animals (2) The involvement of these different organisms in our daily life and the importance of ecology and biodiversity. The organization and functions of complex biological organisms: 6 Hrs (1) The structure and functions of plants and the importance of plants (2) The structure and functions of animals – human as an example (3) Organization of tissues, organs and functional systems in human The cell: 6 Hrs (1) The building blocks of biological organisms (2) Structure and functions of Subcellular organelles (3) Different types of cells (4) Cell division and proliferation The heredity: 6 Hrs (1) The genetic material; General structure of DNA and RNA (2) The genetic information in the form of genes (3) Expression of genetic information -- 1 of 2 -- (4) Passing of genetic information to offspring Modern biotechnology: 6 Hrs (1) Major developments: In vitro fertilization; Gene cloning; GM foods; GM organisms; Human genome project; Gene therapy; Stem cell therapy; Human cloning (2) Impacts of biotechnology on our life and the environment (3) Ethical, social and legal issues

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ABCT1D09abct3 credits

Green House Gases and Life

/ Indicative Syllabus Basic principles and fundamentals of environmental science and technology will be introduced in this course. Common ideas of green house gases and their impact on environment will also be introduced. (a) Essentials of green house gases (carbon dioxide and others) - sources and industrial revolution - air pollution issues - chemical/biological reactions and environmental interaction - market of carbon/green house gases -- 1 of 4 -- (b) Role of government, industry and society - technology to handle green house gases - law and regulation - education - global warming and Kyoto Protocol (c) Impact to ecology - introduction - unpredictable climate changes - What controls the carbon balance of ecosystems? - How do ecosystems influence climate? - other consequences

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ABCT1D11Dabct3 credits

Life without Fossil Fuel

/ Indicative Syllabus 1. Introduction to the present scenario (1 hour) a. Latest statistics on fossil fuel reserve b. Global warming c. Energy generation related pollution 2. Renewable energy technology (12 hours) a. Wind energy b. Hydro and Tidal energy c. Geothermal energy d. Solar energy e. Biomass energy 3. The need of energy storage (2 hours) a. Intermittence of renewable energy b. Mechanical energy storage c. Massive electrochemical storage d. Hydrogen as an energy carrier e. Other organic compounds as energy carrier 4. Present Policy on renewable energy (1hour) a. Kyoto Protocol b. Copenhagen Climate Change Conference c. Energy security d. Hong Kong policy on renewable energy -- 1 of 4 --

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ABCT1D12abct3 credits

Science behind Crime Scene Investigation (CSI)

/ Indicative Syllabus Brief introduction to crime scene investigation (3 Hrs) Arson investigation (6 Hrs) • The fundamental chemistry of fire • Evidence collection and analysis: basic principle of chromatography Investigation of explosions (3 Hrs) • The fundamental chemistry of explosions • Detection of explosives: how does mass spectrometry work? Nuclear terrorism (3 Hrs) • The stories of nuclear isotopes • Applications of nuclear isotopes • Detection of radioactivity Forensic analysis of physical evidence (6 Hrs) • Hairs, fingerprints, questioned documents, etc • Evidence analysis: use of microscope, etc Fundamental forensic toxicology (9 Hrs) • Common poisons and drugs of abuse • Methods of analysis: basic principles of immunoassay, GC-MS and LC-MS -- 1 of 4 -- Identification of victims and suspects: DNA analysis (6 Hrs) • DNA, genes and their relationship to individuality • Basic principles of forensic DNA analysis and DNA profiling Summary (3 Hrs)

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ABCT1D13abct3 credits

Introduction to cancer – cause, treatment and prevention

/ Indicative Syllabus INTRODUCTION TO CANCER: 2 Hrs The nature of cancer COMMON CANCERS IN HK: EPIDEMIOLOGY AND ETIOLOGY 6 Hrs Nasopharyngeal carcinoma Liver Cancer Cervical Cancer Breast Cancer Colorectal Cancer Hematological Malignancies -- 1 of 3 -- FUNDEMENTAL PRINCIPLES OF CANCER: 4 Hrs Brief introduction of cancer biology and cancer genetics TUMOUR VIRUSES 4 Hrs Introduction to virus Tumour viruses and oncogenes Tumour viruses and tumour suppressor genes CANCER & POLYMORPHISM 2 Hrs BASIC CONCEPTS OF ANGIOGENESIS, INVASION & METASTAIS 2 Hrs COMMON DIAGNOSTIC METHODS 3 Hrs Common practice of diagnostic methods Blood, Urine, Pap Tests, Biopsies Cytogenetics and Molecular tests CANCER TREATMENTS 4 Hrs Common treatment modalities Radiotherapy Surgery Chemotherapy Side effects of traditional chemotherapy TARGETED THERAPIES 4 Hrs What is targeted therapy? Small molecules and monoclonal antibodies Progress and future CANCER PATIENTS & THEIR CHALLENGES Awareness of the challenges faced by individuals living with cancer 2 Hrs

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ABCT1D14abct3 credits

Chemistry and Sustainable Development

/ Indicative Syllabus What the weather forecast never tells you: Acid Rain and Global Warming • Combustion and the major sources of energy • Global Warming and green house gases • Kyoto protocol in the political arena • Acid rain and environmental concerns Burn! Let it burn··· • Renewable energy sources • Solar Energy • Biofuels and other alternatives Water – Scarcity of the abundant • Water and our health • What do we mean by clean water? Ions in water and the concept of pH, conductivities • Water Pollutions due to human activities: sewage and contamination from industries and agricultures • Water cycle – water purification in nature • Water treatment in Hong Kong and common water purification technology Look! There is a hole in the sky • Structure of the earth atmosphere • Effects on ozone layer depletion and ozone hole • Problems arise from the use of halogenated hydrocarbons (a type of refrigerant). • Ozone-friendly materials

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ABCT1D15abct3 credits

Our Endangered Earth

/ Indicative Syllabus We will begin with exploring the beauty of our natural environment and what it provides for us. Then we will move into some major environmental topics and look at each of them in details, discussing their causes and consequences, distinguishing genuine crisis from false ones based on scientific reasoning and evidence, and what each of us can do to combat them. Our green inheritance and limited planet (6h) • Guardians of the environment – Is it our mission? • Our daily bread –Importance of solar energy, fertile soil and water to provide for us • Green medicine – Potential medicinal use of living organisms and their conservation • Maintenance of natural resources – Changes in ecosystems by human activities, e.g. desertification and deforestation The crisis (27h) • Natural catastrophes – Asteroid impact, earthquake, tsunami, volcanic -- 1 of 4 -- eruption, typhoon, tornado, flood, severe drought and landslide- how likely are they, and should we be afraid? • Energy supply – How much do we use and how much do we have? What is the problem? Any possible solution? • Wastes, chemicals and environmental pollution – Reuse, reduction, recycle and disposal of waste, natural and artificial recycling of materials, health hazards of improper disposal. • Disease – Diseases in human history and future. Use and misuse of antibiotics and other drugs, the origins of zoonotic diseases and public health crisis. • Threats on wild-life – Extinction of species and its many causes. How to assess vulnerability of species and what we can do to help. • Biotechnology and the environment – What have we achieved? What are the possible consequences of genetic manipulation? Is GM food really bad for us? • Global climate change –What are the causes and consequences? Can it be prevented? Examples of concepts and ideas to be covered in this course o Green and environmental labeling o Green capitalism o Ecological footprint, carbon footprint, carbon credit o Eco-tourism

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ABCT1D16abct3 credits

Introduction to vaccines – history, development and impact

/ Basic concepts of vaccination A: Introduction to vaccines: 6 Hrs The history of vaccination Infections and mechanisms of disease induction Basic concepts of immunity and protection against infection Types of vaccines and their development Different ways of vaccine application (injections and others) B: Common vaccines used in modern times: Spread of infection and how they cause diseases 8 Hrs Implementation of vaccination A: Global vaccination programmes 4 Hrs Extended Program of Immunization (EPI) for children Disease-eradication programs using vaccines Mother and child protection via vaccines Pandemic and seasonal influenza vaccination Global partnerships for immunization B: Vaccination policy and implementation 2 Hrs Making a vaccine A: Making a vaccine and its approval for use in human 4 Hrs Targets for vaccine development

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ABCT1D18abct3 credits

Modern Day Material Sciences

/ Indicative Syllabus Basic principles and fundamentals of modern materials and their applications will be covered. The design and characterization of the materials based on their nature will be discussed. The working principles, operation mechanism as well as impact to human life will be introduced in this course. In addition, we will invite ABCT scientists, who are working in modern materials to share their journey Details of Indicative Syllabus: (a) Materials for biomedical application, labelling, and other possible usage for industry -- 1 of 6 -- 2 1.) The design, working principle and nature of various imaging techniques, such as MRI, CT, and optical imaging, will be introduced. The mechanism of how imaging agents enhance the results by providing more information about biological systems. 2.) Nano-materials have been developed and can be used as non- erasable labels/barcodes for official/legal documents and manufacturing industries to prevent fraud and counterfeiting. They also prevent fading and ensure information remains intact. These materials can also be applied in the manufacturing industry. 3.) Nano size core-shell antimicrobial particles have been developed and can be used in medicine, food packaging, and water treatment to improve public health and safety. (b) Materials for renewable energy The principles of catalysis and how they are applied in renewable energy sources, including solar, biomass, and geothermal energy harvest. Different types of catalysts, such as photocatalysts, homogenous and heterogeneous electrocatalysts, and biocatalysts, as well as strategies for performance optimization will be discussed. The design and nature of the materials will be covered. We will also discuss the applications of catalysis in the production of energy carriers, starting at a basic level, and include sections on adsorption and surface science, catalytic kinetics, and studying key characteristics of emerging nanomaterials that are effective catalysts in renewable energy applications. (c) Organic light-emitting devices (OLEDs) The rapid developments of cutting-edge research on photofunctional organic semiconductor materials are greatly promoting the progress of science and technology in optoelectronic devices. As one of the most important applications of organic semiconductor materials, organic light-emitting devices (OLEDs) are promising candidates for solid-state lighting and full color displays in future owing to their appealing advantages (e.g., high luminance, high contrast, wide viewing angle, ultrathin, large-area, lightweight, flexibility, low-cost, and low-power consumption, etc.). In this topic, the basic science of advanced functional materials involved in OLEDs and the device working mechanisms will be covered in details. The design and nature of the materials will also be covered. (d) Wearable materials Many new developments in recent years include the use of flexible and stretchable materials that can be integrated into clothing and other wearable items. The materials include conductive polymers, nano carbon and other advanced materials that can be used to create high- performance batteries, supercapacitors and other energy storage devices. Other recent developments in wearable materials include the use of smart fabrics and textiles that can help to monitor various health -- 2 of 6 -- 3 parameters. The advancements in wearable materials have the potential to greatly improve the functionality, durability and comfort of wearable devices, opening up new possibilities for their use in various applications. The design and nature of the materials will also be covered. (e) Soft Robotic Movement is one of the vital features in living systems to allow various functions related to survival and reproduction. Some of the naturally existing protein motors, e.g., myosin in muscle tissue, are employed to produce motility by amplification of collective molecular motions from nanoscale up to macroscopic dimensions. Advancements in manufacturing processes and materials science have enabled various state-of-the-art technological developments. For instance, conversional hard robotics, which are produced from rigid structural materials, enable energy conversion to mechanical motions for animal-like functions, e.g., expansion, contraction, and stiffness change. Soft robotics are recently considered as the complementary counterpart to hard robotics. Although soft robotics remain their technological infancy, they could potentially create the next generations of biocompatible and safe actuating robotic systems, to provide a link between living systems and artificial systems at multiple levels. The design and nature of the potential materials will also be covered.

ABCT1D19abct3 credits

Fun Facts of Scientific Discoveries

/ Indicative Syllabus Basic principles and fundamentals of interesting and important chemistry and biology experiments will be introduced. The mechanism and possible application of science and technology will be discussed in this course. Details of Indicative Syllabus: (a) Impactful stories in science Examples: - cause of global warming and the importance of carbon neutrality - discovery of porous materials including (activated carbon, zeolite, and metal-organic frameworks) and their properties - discovery of a new MOF (from lab to pilot plant scale) -- 1 of 4 -- 2 - development on organic thermoelectric materials: from design to synthesis - making sense of organometallic complexes, as well as semiconducting materials - discovery of organic light-emitting diodes (OLEDs) - story of aggregation-caused quenching (ACQ) and aggregation-induced emission (AIE) phenomena (b) Science of interesting and eye-catching experiments (I) Fundamental principles of selected experiments will be discussed and demonstrated. Factors that affect the experiments will be discussed. (II) Laboratory learning for interesting experiments - The emission behaviours of various aggregations containing perylene and 1,1,2,3,4,5-hexaphenylsilole (HPS) as representative luminophores will be investigated to discern the distinct phenomena of aggregation-caused quenching (ACQ) and aggregation-induced emission (AIE) - The experimental design involved preparing a series of solutions containing different aggregation states of perylene and 1,1,2,3,4,5- hexaphenylsilole (HPS), measuring the luminescent properties of the solutions, observing ACQ and AIE phenomena, and exploring their luminescence mechanisms from the perspective of molecular crystal structure

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ABCT1D20abct3 credits

Science of Happiness

/ Indicative Syllabus Basic principles and fundamentals of chemical and biological factors inside our brain and body leading to happiness will be covered. The function of hormones and chemicals will be introduced in this course. The positive values of healthy life habits and life style, positive attitude, regular exercise will be introduced in this subject. Details of Indicative Syllabus: Part I. Sciences of happiness (a) Understanding the function of hormones that increase positive emotion - “What are happy hormones?” - “How does the body sense happiness?” Explain from scientific aspects - Serotonin: neurotransmitter that carries messages between nerve cells that affect sleep -- 1 of 4 -- 2 - Dopamine: neurotransmitter that can affect mood, memory, motivation, sleep and plays a role as a ‘reward centre’ and important in sensations of pleasure - Endorphins: hormones related to body pain or stress - Oxytocin: hormone related to reproductive functions and human behaviour including romantic attachment, parent-infant bonding, etc. - Ways to boost “Happy Hormones” - spending time outdoors, in sunlight - regular exercise - laughing - certain food e.g., green tea, chocolate, red wine, etc. - music (b) Chemicals and Mood - Caffeine in coffee and tea - Chocolate chemicals related to happiness - Pyrazine and antioxidants in food - Alcohol e.g., polyphenols in red wine - Psychoactive drugs: many prescription drugs used to treat psychological disorders alter the effects of neurotransmitters e.g., Tranquilizers activate receptors and reduce neurotransmitter’s effect - The mechanism of action will be introduced e.g., absorption of chemicals in gut and cross into brain which affect the effect of neurotransmitters (c) Exercise and Mood - exercise can keep us healthy, decrease anxiety and enhance learning, thinking and judgement. - exercise can reduce risk of depression and improve sleeping pattern, reduce neurodegeneration diseases (d) Scientific aspects of drug addiction and abuse -biological perspective: changes in brain’s reward system, which is responsible for regulating feelings of pleasure and motivation. -chemically, drugs interact with specific receptors in the brain, altering the transmission of signals between neurons Part II. Laboratory/workshop classes The laboratory/workshop include classes of team building activities, simple physical group/individual exercises as well as students’ competition and sharing. After the laboratory/workshop, students are required to investigate the level of happiness by the collection of peers’ responses through the use of questionnaire survey and group interview.

ABCT2001abct1 credits

Lab Techniques in Biological Sciences

/ Indicative Syllabus Experiments involved may included 1. use of the microscope and proper aseptic laboratory techniques 2. identify microbes through the use of cultures and staining techniques 3. apply the basic biochemical techniques on enzyme characterization and metabolite assays 4. interpret and analyze biochemical data. e.g. develop analytical, critical thinking, and written communication skills

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ABCT2101abct3 credits

Biochemistry

/ Indicative Syllabus Carbohydrate & lipids: structure, properties and functions (6 hours) Amino acids, peptides and proteins (6 hours) Case studies of proteins: structure-function relationship (6 hours) Basic principles of enzymology: enzyme kinetics and mechanism (6 hours) Bioenergetics: glycolysis, TCA cycle, beta-oxidation and OXPHOS (15 hours)

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ABCT2102abct3 credits

Molecular Biology

/ Indicative Syllabus Mendelian Genetics Non-Mendelian Genetics The genetic materials and chromatin: Composition and structure of DNA and RNA, organization of DNA in chromosomes. Chromosomes: viral genomes. Bacterial genomes. Eukaryotic chromatin and chromosomes, centromeres, telomeres. Chromosomal inheritance and chromosomal abnormalities DNA replication: semi-conservative and semi-discontinuous replication of DNA; the replicon, initiation, DNA polymerases, primase, leading strand and lagging strand; Okazaki fragments. Transcription: prokaryotic promoters and terminators; RNA polymerase and sigma factors. Eukaryotic promoter elements, promoter proximal elements, enhancers, general transcription factors, activators; 5’-capping, 3’- polyadenylation, splicing of transcript. Translation: Initiation, elongation, and termination processes; the ribosome and the rRNAs. Transposable elements: transposons, jumping genes and retrotransposons. Regulation of prokaryotic gene expression: positive and negative controls, the operon, regulatory RNA (attenuation and termination), phage strategies (lytic vs lysogenic pathways). Regulation of eukaryotic gene expression: Different levels of control, -- 1 of 2 -- transcription factors and transcription regulator proteins; chromatin remodeling; gene silencing by methylation; alternative polyadenylation and alternative splicing.

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ABCT2103abct3 credits

Cell Biology

/ Indicative Syllabus Introduction to cells and Chemistry of Cells Importance of biomolecules in cells, bioenergetics and catalysis. Visualization of cells and subcellular structures with different types of microscopy. Cells and Development Differentiation of cells during embryonic development. Cell types and functions. Structure and Function of Cell Organelles The architecture of plasma membrane, transport across membrane, internal membranes and cell energetic; cytoskeleton and cell movement; endoplasmic reticulum, ribosomes, Golgi apparatus, mitochondrion, and the nucleus. Control of Cell Growth and Cell Death in Eukaryotes Different phases of cell cycle and its regulations; mechanisms of cell death. Control of cell signaling Types of cell signaling. Basis and understanding of cell signaling, major types of signaling cascades. -- 1 of 3 --

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ABCT2133abct3 credits

Human Physiology

/ Indicative Syllabus Nervous system: Generation of the various types of membrane potentials and their interrelationship, roles and significance; mechanisms of generation of receptor potentials; synapses and neurotransmitters; function of the sensory cortex and transmission of nervous modulations from the periphery to the sensory cortex. Effects of drugs and poisons on the function of the nervous system. Cardiovascular system: Structure and function of the heart and blood vessels; role of the pacemaker, nervous and endocrine control of cardiac functions; haemodynamics and blood flow; thrombosis and anticoagulation Respiratory system: Ventilation and lung mechanics; significance of forced vital capacity and expiratory volume exchange; transport of blood gases; mechanism of chemical control of ventilation rate. Digestive system: Digestion and absorption; regulation of the digestive processes. Endocrine system: Organization of the endocrine system; classification and chemistry of hormones; controlling mechanisms of hormone secretion; function of various types of hormones. -- 1 of 3 -- Renal system: Renal reabsorption processes; significance of the long and short loop of Henle; function of the vasa recta; regulation of acid-base balance. Reproductive system: Male and female reproductive physiology; female sex cycle; menopause and the male climacteric; integration with the other systems. Musculoskeletal system (structure of skeletal muscle; classification of muscle and muscle contraction, mechanism of muscle contraction; energy requirement of skeletal muscle; neural control of muscle contraction; structure of bone and cartilage; growth and remodeling of bone; calcium homeostasis)

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ABCT2134abct3 credits

Microbiology

/ Indicative Syllabus Topic Hour Introduction 2  Historical development  Importance of different groups of microorganisms  Areas of study in microbiology Basic microbiological techniques 8 Bacteria 11  Cell structure and function  Microbial taxonomy  Prokaryotic diversity Viruses 6  Classification and characterization of bacteriophages  Animal and plant viruses Fungi and Protists 4  Characteristics, classification and identification Metabolic diversity of microorganisms 7  The various source of energy for microbial metabolism -- 1 of 3 --  The various metabolic pathways specific to microorganisms Microbial nutrition, cultivation and growth  The chemical and physical conditions for microbial growth  Principles and methods for cultivation of various types of microorganisms  Kinetics and mathematical model of microbial growth  Methods of measuring growth 8 Control of microorganisms  Physical and chemical agents  Evaluation of antimicrobial agent effectiveness 4 Total 50

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